Laser lipolysis allows the removal of small volumes of fat with concurrent sub-dermal tissue contraction. However, the physiologic consequences of this procedure are not well documented. The possible effects on serum lipids are not well established. Objective: This study was undertaken to determine what changes, if any, occurred in serum lipid profiles at different intervals (1 day, 7 days, 2 weeks and 1 month) after the procedure. Methods: Four consecutive patients were included in the study.